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Target intelligence / Profile preview
Immunoglobulin-like Transcript 4 Receptor (ILT4)
- Target
- ILT4
- Molecular classification
- Receptor, Leukocyte immunoglobulin-like receptor (LILR)
01
Overview
Immunoglobulin-like transcript 4 (ILT4) is an inhibitory receptor primarily expressed on myeloid lineage cells like monocytes, macrophages, and dendritic cells. It belongs to the leukocyte immunoglobulin-like receptor (LILR) family and contains ITIM motifs in its cytoplasmic domain. ILT4 interacts with ligands such as HLA-G and complement C4d, negatively regulating immune responses. It is implicated in cancer, autoimmunity, transplant tolerance, and infection, making it a potential therapeutic target for immune modulation.
- Other names
- LILRB2CD85dLIR-2
02
Mechanism of action
Inhibition of myeloid cell activation via ITIM signaling; enhancement of T cell priming by dendritic cells upon blockade.
03
Biological functions
Immune regulationInhibitory signalingSelf-tolerance
04
Disease associations
CancerAutoimmune diseaseTransplant rejectionInfection
05
Safety considerations
Potential for autoimmunity or transplant rejection with ILT4 blockade.Potential for immune suppression with ILT4 agonism.
06
Biomarkers
HLA-GVEGF-C
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