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Immunoglobulin-like Transcript 7 (ILT7)
- Target
- ILT7
- Molecular classification
- Receptor, Transmembrane protein, Immunoglobulin-like receptor (LIR), Leukocyte immunoglobulin-like receptor (LILR)
01
Overview
Immunoglobulin-like transcript 7 (ILT7), also known as CD85g and LILRA4, is an inhibitory receptor selectively expressed on human plasmacytoid dendritic cells (pDCs). It negatively regulates innate immune responses by suppressing pDC activation and type I interferon (IFN-I) production following stimulation through Toll-like receptors TLR7/9. The natural ligand for ILT7 is bone marrow stromal cell antigen 2 (BST2), also known as tetherin or CD317. Engagement between BST2 and ILT7 leads to suppression of IFN-I secretion by pDCs.
- Other names
- CD85gLILRA4
02
Mechanism of action
Engagement of ILT7 with its ligand BST2 leads to ITAM-mediated signaling via Src/Syk kinases through FcεRIγ, inhibiting pDC activation and IFN-I production.
03
Biological functions
Immune responseInhibition of type I interferon (IFN-I) productionRegulation of innate immunitySignal transduction
04
Disease associations
Viral infectionsAutoimmune diseasesInflammation
05
Safety considerations
Potential for immunosuppressionDysregulation of immune responses
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