Immunoglobulin superfamily member 5 (IGSF5)

Immunoglobulin superfamily member 5 (IGSF5) is a cell–cell adhesion molecule that localizes to tight junctions in epithelial and endothelial tissues, working with other proteins such as MAGI1 to regulate barrier permeability in organs like the kidney and intestine[2][3][4][7]. IGSF5 mediates calcium-independent homophilic interactions and plays a crucial role in maintaining epithelial barrier integrity[1][2][3][4][7]. In the testis, it may function as a more general adhesion molecule important for spermatogonia and Sertoli cell interactions[3][4]. Genetic variation in IGSF5 is associated with altered transcriptional activity and potentially with phenotypic variability in some developmental disorders[1]. IGSF5 has been implicated as an immune-related prognostic biomarker in head and neck squamous cell carcinoma and associated with other conditions including pseudo-TORCH syndrome 1 and autism spectrum disorder[1][3][4]. While its detailed mechanism and interacting partners are still being characterized, disruption of IGSF5 function can influence intercellular adhesion and tissue integrity, impacting both developmental and disease processes[1][2][3][4].

Other names

JAM4Junctional adhesion molecule 4IgSF5GSF5IGSF5phIGSF5Q9NSI5