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Immunoglobulin superfamily member 8 (IGSF8)
- Target
- IGSF8
- Molecular classification
- Immunoglobulin superfamily member, Transmembrane protein
01
Overview
IGSF8 is a transmembrane protein belonging to the immunoglobulin superfamily. It acts as an innate immune checkpoint, inhibiting NK cell cytotoxicity by binding to KIR3DL2. It regulates cell movement, aggregation, proliferation, and morphology through interactions with tetraspanins and integrins. IGSF8 may also function as a tumor suppressor. It is frequently overexpressed in cancers and acts as an adhesion protein involved in T cell and NK cell interactions.
- Other names
- CD316EWI-2EWI2CD81P3KCT-4LIR-D1PGRL[2][5]
02
Mechanism of action
Inhibition of NK cell cytotoxicity via interaction with KIR receptors; Prevention of EGFR clustering/endocytosis.
03
Biological functions
Innate immune checkpoint inhibition of NK cellsRegulation of cell movementRegulation of cell aggregationRegulation of cell proliferationRegulation of cell morphologyCell adhesionCell migrationInhibition of HIV-1 Env-mediated cell-cell fusion
04
Disease associations
CancerGliomaMelanomaUrothelial carcinomaBreast cancerOvarian cancerViral infection
05
Safety considerations
Potential for immune-related adverse events if targeted therapeutically
06
Biomarkers
IGSF8 overexpression in cancerIGSF8 enrichment on ovarian cancer-derived extracellular vesicles
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