Immunoglobulin superfamily member 9B (IGSF9B)

Immunoglobulin superfamily member 9B (IGSF9B) is an evolutionarily conserved, brain‐specific cell adhesion molecule selectively localized to inhibitory synapses of GABAergic interneurons. It organizes distinct subsynaptic domains and interacts with synaptic organizers such as Neuroligin-2 through scaffolding molecules like S-SCAM/MAGI-2, supporting inhibitory synapse development and maintenance[1][2][3]. IGSF9B shows activity-dependent, cell type-specific expression in the brain and is involved in the regulation of inhibitory postsynaptic potential, synaptic transmission, and neural circuit plasticity. Genetic variants in IGSF9B have been associated with neuropsychiatric disorders including schizophrenia and major depression, as well as with neurodevelopmental circuit changes and anxiety behaviors in animal models. To date, IGSF9B is not a classical pharmacological target but remains of interest in neuroscience for understanding inhibitory synaptic architecture and brain disease mechanisms[1][2][3].

Other names

IGSF9BProtein turtle homolog BKIAA1030IgSF9BLINC00947LOC283174Immunoglobulin superfamily member 9BTurtle (Drosophila) homolog BMIR4697HGMIR4697 host gene (non-protein coding)Long intergenic non-protein coding RNA 947