Immunomodulation via Engineered Donor Allograft Cells

Immunomodulation via engineered donor allograft cells is a therapeutic strategy that involves modifying donor-derived cells to express immunoregulatory molecules. These engineered cells are used in transplantation to promote immune tolerance, reduce rejection, and minimize the need for systemic immunosuppression by inducing local or systemic immune tolerance specific for donor antigens, reducing effector T-cell–mediated graft rejection, and expanding or recruiting regulatory T-cells within the graft microenvironment.

Other names

Engineered donor cell therapyDonor cell immunomodulationTolerance induction via engineered allografts

Engineered donor cells induce tolerance through various mechanisms, including FasL-mediated apoptosis of effector T cells, PD-L1/PD-1 checkpoint inhibition, and CTLA4/B7 costimulatory blockade, ultimately reducing effector lymphocyte activity and enhancing regulatory mechanisms.