Immunomodulation via exogenous donor-derived B cells (N/A)

Immunomodulation via exogenous donor-derived B cells refers to the therapeutic administration of B lymphocytes sourced from a donor, with the aim of modulating immune responses in the recipient. This approach leverages the multifaceted roles of B cells beyond antibody production, including their capacity to regulate inflammation, present antigens, and shape tissue microenvironments. Donor-derived B cells can secrete cytokines (IL-10, TGFβ, TNFα), influence myeloid populations promoting regulatory phenotypes, and alter the microenvironment at sites of injury/inflammation. Potential applications include autoimmune diseases, transplantation tolerance induction, neuroinflammatory conditions, and injury repair.

Other names

Exogenous B cell therapyAllogeneic B cell therapyDonor-derived B cell immunomodulation

Administration of donor-derived B cells to modulate immune responses through cytokine secretion, interaction with myeloid and T cell populations, and antigen presentation.