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Target intelligence / Profile preview
Immunomodulation via Paracrine Signaling
- Molecular classification
- Signaling pathway, Cell-cell communication, Secreted factors
01
Overview
Immunomodulation via paracrine signaling describes the regulation of immune responses through the secretion of soluble factors, primarily by mesenchymal stromal/stem cells (MSCs). These factors, including cytokines, chemokines, growth factors, and extracellular vesicles (EVs), influence the behavior of immune cells in the microenvironment, shifting the immune balance towards anti-inflammatory or tolerogenic states. It is not a single targetable protein, but a process involving multiple secreted factors and pathways.
- Other names
- MSC-mediated ImmunomodulationMesenchymal Stromal Cell Paracrine SignalingSecretome-mediated Immunoregulation
02
Mechanism of action
Secretion of soluble factors (cytokines, chemokines, growth factors, EVs) that modulate immune cell activity.
03
Biological functions
Immune response regulationInflammation modulationTissue regenerationCell signaling
04
Disease associations
Inflammatory diseasesAutoimmune disordersOsteoarthritisLung injuryCancer microenvironment
05
Safety considerations
Potential for unintended immune suppressionVariability in MSC potency and secretome compositionRisk of ectopic tissue formation
06
Interacting drugs
Mesenchymal Stromal/Stem Cells (MSCs)
1 more in the full profile.
07
Biomarkers
Levels of IL-10, TNF-α, CCL2, CCL5, PGE2 in the microenvironmentM1/M2 macrophage polarizationRegulatory T cell population
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