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Target intelligence / Profile preview
Immunoproteasome (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Protease, Proteasome subunit
01
Overview
The immunoproteasome is an inducible variant of the standard proteolytic machinery essential for adaptive immunity via efficient generation of antigenic peptides presented on MHC class I molecules. Its unique structure confers altered substrate specificity suited to this role. Beyond antigen processing, it influences broader aspects of cellular homeostasis—including inflammatory signaling—and represents an emerging therapeutic target across autoimmunity and oncology contexts.
- Other names
- LMP2MECL-1LMP7β1iβ2iβ5iPSMB9PSMB10PSMB8
02
Mechanism of action
Selective inhibitors targeting immunoproteasomal subunits are being developed to modulate immune responses and inhibit cancer cell growth.
03
Biological functions
Antigen processingImmune responseCytokine modulationRegulation of NF-κB pathwayOxidative stress response
04
Disease associations
AutoimmunityInflammationCancerAutoinflammatory syndromes
05
Safety considerations
Potential for immunosuppressionOff-target effects on constitutive proteasome functionDevelopment of resistance
06
Interacting drugs
Bortezomib
1 more in the full profile.
07
Biomarkers
Expression levels of immunoproteasome subunits in patient tissuesChanges in cytokine profilesMHC class I peptide presentation
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