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Target intelligence / Profile preview
Immunoproteasome caspase-like site β1 (None)
- Target
- None
- Molecular classification
- Enzyme, Protease, Proteasome subunit
01
Overview
The immunoproteasome caspase-like site β1, also known as LMP2 or PSMB9, is a catalytic subunit of the immunoproteasome. It exhibits caspase-like activity, cleaving peptide bonds after acidic residues. It plays a crucial role in antigen processing and MHC class I presentation, impacting immune responses and inflammation. As a therapeutic target, selective inhibitors are being explored for autoimmune and inflammatory diseases.
- Other names
- LMP2β1iPSMB9
02
Mechanism of action
Inhibition of caspase-like proteolytic activity
03
Biological functions
Antigen processingMHC class I presentationProtein degradationRegulation of inflammationImmune response
04
Disease associations
Autoimmune diseasesInflammatory diseasesCancerInfection
05
Safety considerations
Potential for off-target effects due to homology with constitutive proteasomeAltered antigen presentation may have unintended immunological consequences
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