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Target intelligence / Profile preview
Immunoproteasome subunit beta type-1i (β1i)
- Target
- β1i
- Molecular classification
- Enzyme, Proteasome subunit
01
Overview
Immunoproteasome subunit beta type-1i (β1i), also known as LMP2, is an inducible catalytic subunit of the immunoproteasome. It plays a central role in antigen processing for MHC class I presentation and influences inflammatory responses. Selective inhibitors are under investigation as potential therapeutics for autoimmune disorders and certain cancers. Deficiency or mutation impairs proper peptide processing for MHC class I presentation.
- Other names
- LMP2RING12MC7PSMB9
02
Mechanism of action
Selective inhibitors targeting this subunit are under investigation.
03
Biological functions
Antigen processingAntigen presentationImmune responseRegulation of inflammationModulation of T cell polarization
04
Disease associations
Autoimmune diseasesCancerInfectionInflammation
05
Safety considerations
Altered immune function
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