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Target intelligence / Profile preview
Immunoproteasome subunit beta type-8 (LMP7)
- Target
- LMP7
- Molecular classification
- Enzyme, Protease, Proteasome subunit
01
Overview
Immunoproteasome subunit beta type-8 (LMP7) is a catalytic subunit of the immunoproteasome, a specialized form of the proteasome complex. It plays a central role in protein degradation, antigen processing for MHC class I presentation, and regulation of immune responses. LMP7 exhibits chymotrypsin-like activity and is upregulated by interferon-gamma (IFNγ). Selective inhibitors targeting LMP7 are being explored therapeutically in autoimmune diseases. Deficiency/mutations are linked with autoinflammatory syndromes.
- Other names
- PSMB8β5i
02
Mechanism of action
Selective inhibition of LMP7
03
Biological functions
Antigen processingMHC class I presentationProtein degradationImmune response regulationApoptosisInflammation control
04
Disease associations
Autoimmune diseasesAutoinflammatory syndromesCancerInfection
05
Safety considerations
Potential for compensatory upregulation of other proteasome subunits
06
Interacting drugs
ONX0914
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