Immunosuppressive activity

Immunosuppressive activity refers to a biological property or process that reduces or inhibits immune system function. This effect can be caused by specific drugs, regulatory cell types (such as regulatory T cells, B cells, and myeloid-derived suppressor cells), tumor-derived factors, or pathogens. Immunosuppressive mechanisms include inhibition of cytokine production, suppression of immune cell proliferation, induction of immune cell death (via death receptor pathways), modulation of antigen presentation, and promotion of immune cell regulatory subsets. While deliberately induced immunosuppression benefits patients with organ transplants and autoimmune diseases, it increases susceptibility to infections and cancers, and carries additional risks and clinical management challenges[1][2][3][4][5][6][7].

Other names

immunosuppressionimmunosuppressive effect

Inhibition of cytokine production (e.g., IL-2 suppression); Inhibition of immune cell proliferation (T and B cells); Blocking co-stimulatory signals (e.g., CTLA-4, PD-1 engagement); Induction of immune cell death (Fas/FasL, TRAIL/TRAILR, TNF); Modulation of antigen presentation