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Target intelligence / Profile preview
Immunosuppressive cell expressing Natural killer group 2 member D ligand
- Molecular classification
- Cell
01
Overview
Immunosuppressive cells that express NKG2D ligands (MICA, MICB, ULBP1-6) can interact with the NKG2D receptor on NK and T cells. This interaction is central to immune surveillance but can also play a role in immune regulation and evasion. Tumor cells, viral-infected cells, and immunosuppressive cells may shed soluble forms of these ligands (sNKG2DL), which can downregulate surface expression on tumor/targeted tissues. Transforming growth factor-beta (TGF‑β) further suppresses effector function. Therapeutic strategies include enhancing ligand expression for cancer therapy or blocking soluble ligand effects to restore antitumor immunity.
02
Biological functions
Immune suppressionImmune evasionAntigen presentationT cell inhibitionNK cell inhibition
03
Disease associations
CancerViral InfectionAutoimmunityTransplantationInflammation
04
Safety considerations
Immune suppressionTumor escape
05
Biomarkers
MICAMICBULBP1ULBP2ULBP3ULBP4ULBP5ULBP6
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