Impact homolog pseudogene

Impact homolog pseudogene" (ENSG00000256465) is a human pseudogene, derived by duplication or retrotransposition from a functional IMPACT gene ancestor.[1][2][7] Pseudogenes are generally defined as DNA sequences with close homology to functional genes but that have lost their ability to code for functional proteins, either because of disruptive mutations (such as premature stop codons or indels) or loss of regulatory regions.[1][4] Although some pseudogenes can be transcribed or may play minor roles as regulators of gene expression (e.g., via RNA interference or as competing endogenous RNA sponges), in the vast majority of cases—including this one—no protein product is made and there is no evidence of physiological, pathological, or pharmacological relevance.[2][7] This pseudogene is not a canonical drug target and has no known role as a biomarker or in disease, nor does it interact with therapeutic agents.