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Importin Subunit Beta 1

Molecular classification: Karyopherin, Transport Receptor

Overview

Importin subunit beta-1 (KPNB1) is a key protein in the nuclear import pathway. It mediates the transport of proteins from the cytoplasm into the nucleus through nuclear pore complexes (NPCs). It forms a heterodimer with importin alpha to recognize cargo proteins containing nuclear localization signals (NLS) and docks this complex at the cytoplasmic side of NPCs. KPNB1 is overexpressed in some cancers, making it a potential therapeutic target. Inhibition disrupts proteostasis and triggers apoptosis.

Other names: Karyopherin subunit beta 1KPNB1

Mechanism of action

Inhibition of KPNB1 disrupts nuclear import, leading to cell death.

Biological functions

Nucleocytoplasmic transportProtein import into nucleusCell cycle regulationStress responseViral infection processes

Disease associations

Cancer

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