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"Improved circulation" refers to the enhancement of blood flow throughout the circulatory system, commonly targeted as a therapeutic endpoint in cardiovascular disease. This effect is typically achieved by modulating diverse molecular targets such as ion channels, G protein-coupled receptors, vasoactive enzymes (e.g., nitric oxide synthase, angiotensin-converting enzyme), and signaling molecules affecting vascular tone, smooth muscle cell contraction, or endothelial function[1][4][2]. However, "Improved circulation" itself is not a discrete molecule or receptor but rather the result of modulating these underlying pathways.
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