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Target intelligence / Profile preview
Poliovirus Type 3 Antigen (Inactivated) (IPV3)
- Target
- IPV3
- Molecular classification
- Viral Antigen, Picornavirus Protein
01
Overview
Poliovirus type 3 antigen (inactivated) is a purified, inactivated form of the poliovirus type 3, used as a component in the inactivated poliovirus vaccine (IPV). It stimulates an immune response without causing disease. Upon vaccination, recipients develop neutralizing antibodies against poliovirus type 3. Neutralizing antibodies target specific epitopes on the viral capsid proteins, particularly VP1 and VP2, preventing viral entry into host cells.
- Other names
- Inactivated Poliovirus Type 3Salk Poliovirus Type 3Type 3 Poliovirus Vaccine Antigen
02
Mechanism of action
Stimulates production of neutralizing antibodies against poliovirus type 3, preventing viral entry into host cells.
03
Biological functions
Antigen presentationInduction of neutralizing antibody responseImmune response
04
Disease associations
Prevention of PoliomyelitisInfection
05
Safety considerations
Potential for allergic reactionsRare instances of vaccine-associated paralytic poliomyelitis (VAPP) with OPV, but not IPV
06
Interacting drugs
Inactivated Poliovirus Vaccine (IPV)
2 more in the full profile.
07
Biomarkers
Serum neutralizing antibody titers (≥1:4)
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