Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1)

HSDL1 (Inactive hydroxysteroid dehydrogenase-like protein 1) is a member of the short-chain dehydrogenase/reductase (SDR) superfamily, designated SDR12C3. Despite its name, it is annotated as "inactive" or "like" a dehydrogenase; evidence for direct enzymatic (dehydrogenase) activity is lacking, and its biological roles are not well characterized. It is not known as a prominent therapeutic target, and there are no widely established roles in physiology, pathology, or drug interaction profiles in the current biomedical literature. Key clarification: There is a potential for confusion with 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1, HSD11B1)—a well-established metabolic enzyme and therapeutic target[1][2][3]. However, HSDL1 and 11β-HSD1 are distinct proteins, encoded by different genes and with different biological significance. Summary of core facts for structuring: HSDL1 is not widely considered a therapeutic target, nor has it been strongly implicated in disease mechanisms or drug development. There is nothing inherently misspelled in your provided names, but the biological/therapeutic significance is very limited, and it should not be confused with 11β-HSD1, which is the pharmacologically relevant target in metabolic diseases.

Other names

HSDL1SDR12C3Short chain dehydrogenase/reductase family 12C member 3steroid dehydrogenase-like protein