Inactive phospholipase C-like protein 2 (PLCL2)

Inactive phospholipase C-like protein 2 (PLCL2) is a member of the phospholipase C (PLC) protein family that, while structurally related to active PLC enzymes, lacks enzymatic activity. Unlike classical PLCs, which hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) to generate second messengers and control calcium signaling[1][3], PLCL2 lacks the essential catalytic residues and instead participates in regulatory roles within signaling pathways. It is specifically involved in GABA receptor binding, modulation of immune cell functions (particularly B cells), and plays a part in regulating the GABAergic synaptic transmission and responses to cold-induced thermogenesis[2][4]. Genome-wide association studies implicate PLCL2 in cardiovascular diseases (including myocardial infarction and atherosclerosis) and as a tumor suppressor whose loss can contribute to colon cancer[2][4]. PLCL2’s primary biological importance is regulatory, modulating diverse processes through protein-protein interactions and signaling scaffolding, especially in hematopoietic cells and neuronal tissues[2][4]. There are currently no drugs in clinical use that directly target PLCL2.

Other names

PLCE2KIAA1092PLC-L2PLC-epsilon-2Phospholipase C-L2phospholipase C-epsilon-2PLC-L(2)