Inactive phospholipase D5 (PLD5)

Inactive phospholipase D5 (PLD5) is a member of the phospholipase D enzyme family, predicted to localize to the membrane. Despite its annotation, PLD5 lacks essential active site residues found in canonical phospholipase D enzymes, making it likely catalytically inactive with respect to phosphatidylcholine hydrolysis. Recent studies implicate PLD5 as a risk gene in neurodevelopmental disorders, notably autism spectrum disorder, and as an oncogene that promotes tumor progression in prostate cancer, particularly influencing cell proliferation and metastasis. PLD5's expression is suppressed by miR-145-5p, which curtails its oncogenic effects, underscoring its significance as a potential biomarker and a candidate for further research in human disease pathogenesis. As of now, PLD5 is not a target of approved drugs, and its precise molecular mechanism remains under investigation.

Other names

Inactive phospholipase D5PLD5PLDCInactive choline phosphatase 5Inactive phosphatidylcholine-hydrolyzing phospholipase D5FLJ40773

Not applicable (no drugs reported that target PLD5 directly)