Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B (MINDY4B)

Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B (MINDY4B) is a member of the MINDY family of putative deubiquitinase enzymes, predicted to specifically target K48-linked ubiquitin chains for deubiquitination, although it is characterized as "inactive" and its enzymatic activity has not been experimentally demonstrated[1][2][4][7][8]. MINDY4B is a protein-coding gene with tissue expression observed in various human tissues, but its physiological roles and relevance as a therapeutic target are currently unclear[3]. Diseases reported to be associated with this gene include autosomal dominant deafness and glioma susceptibility, but direct mechanistic links require further investigation[1]. There are no known approved drugs or established biomarkers targeting MINDY4B, and it is not presently considered a validated therapeutic target.

Other names

C3orf76FAM188B2Protein FAM188B2family with sequence similarity 188 member B2putative UPF0526 protein Bepididymis secretory sperm binding protein