Inactive ubiquitin thioesterase OTULINL (OTULINL)

Inactive ubiquitin thioesterase OTULINL (OTULINL) is a protein coding gene in humans, located on the cytoplasmic side of the endoplasmic reticulum membrane and nuclear envelope[2]. It is structurally similar to the deubiquitinase OTULIN (FAM105B), but lacks the conserved catalytic cysteine in the active site, being substituted by an aspartate residue, rendering it catalytically inactive[6][3][7][8]. The molecular structure of OTULINL (FAM105A) reveals deficiencies in both its active site and its substrate binding site, which confirms its classification as a pseudo-deubiquitinase[3][7][8]. Functionally, OTULINL appears to participate in protein-protein interactions rather than ubiquitin cleavage, but the precise biological roles remain unclear. Unlike OTULIN, which has critical roles in immune signaling, cell death, and NF-kB regulation, OTULINL has no established functional role in canonical ubiquitin-dependent processes or disease mechanisms[1][2]. Direct drug interactions, mechanism of action, biomarker utility, or safety issues have not been reported for OTULINL[2][3][6].

Other names

OTULINLFAM105ANET20FLJ11127inactive ubiquitin thioesterase OTULINLfamily with sequence similarity 105 member Aprotein FAM105A