Induced hepatocyte-like cell (iHEP or HLC)

Induced hepatocyte-like cells (iHEPs or HLCs) are derived from pluripotent stem cells (such as iPSCs) or directly reprogrammed from non-hepatic somatic cells using growth factors, small molecules, or miRNAs. These cells closely mimic primary hepatocytes in morphology and function, capable of secreting albumin, producing urea, storing glycogen, and expressing metabolic enzymes including cytochrome P450s. Transplantation of iHEPs into injured or failing livers in animal models has demonstrated restoration of liver function, stimulation of liver regeneration, reduction in fibrosis, cytoprotective effects, and improvement in survival. While promising as a therapy for liver failure and certain chronic liver diseases, challenges include achieving complete and stable maturation, efficient engraftment, and ensuring long-term safety.

Other names

induced hepatocytehepatocyte-like celliHEPHLCiHepchemically induced hepatocyte (CiHep)hepatocyte differentiated from pluripotent stem cell

Engraftment and repopulation of liver parenchyma; Functional replacement of damaged hepatocytes (albumin secretion, urea synthesis); Anti-fibrotic protein secretion; Modulation of local cytokine secretion and immune responses; Promotion of endogenous liver regeneration