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Target intelligence / Profile preview
Induced Myeloid Cell Leukemia 1 Protein (Mcl-1)
- Target
- Mcl-1
- Molecular classification
- BCL-2 family protein, Anti-apoptotic protein
01
Overview
Induced myeloid cell leukemia 1 protein (Mcl-1) is a member of the BCL-2 family of proteins that regulates apoptosis. It acts as an anti-apoptotic factor by sequestering pro-apoptotic proteins like Bak and Bax, preventing mitochondrial outer membrane permeabilization. Mcl-1 expression is tightly regulated at multiple levels, and its overexpression is common in cancers, contributing to tumor survival and drug resistance. Therapeutic strategies target Mcl-1 through direct inhibition of the BH3-binding groove, transcription inhibition, translation inhibition, or promoting its degradation.
- Other names
- Myeloid cell leukemia sequence 1MCL1LMCL1SMCL1ES
02
Mechanism of action
Direct inhibition of BH3-binding groove; transcription inhibition; translation inhibition; promotion of degradation
03
Biological functions
Apoptosis regulationCell survivalDNA repairMitochondrial energy production
04
Disease associations
CancerDrug resistance
05
Safety considerations
Essential physiological roles across tissuesPotential for off-target effectsEmbryonic lethality with complete loss of function
06
Interacting drugs
Flavopiridol
3 more in the full profile.
07
Biomarkers
MCL1 expression levelMCL1 amplification
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