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Target intelligence / Profile preview
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL-1)
- Target
- MCL-1
- Molecular classification
- Bcl-2 family protein, Apoptosis regulator
01
Overview
MCL-1 is a member of the Bcl-2 family of proteins, functioning primarily as an anti-apoptotic protein by binding and sequestering pro-apoptotic BH3-only proteins. It is essential for the survival and maintenance of various cell types, and its overexpression is implicated in various cancers, making it a target for drug development. The protein has a very short half-life, allowing rapid cellular response to stress signals that affect survival decisions.
- Other names
- Mcl-1Myeloid cell leukemia sequence 1 protein
02
Mechanism of action
Small molecule inhibitors targeting the BH3-binding groove to induce apoptosis in cancer cells.
03
Biological functions
AntiapoptosisCell survivalRegulation of mitochondrial outer membrane permeabilizationRegulation of cytochrome c releaseRegulation of cell deathMitochondrial homeostasisCell cycle progression
04
Disease associations
CancerMultiple myeloma (MM)Acute myeloid leukemia (AML)Non-Hodgkin lymphoma (NHL)Solid tumors
05
Safety considerations
Toxicity due to impact on normal tissue homeostasisBalancing efficacy against toxicity
06
Interacting drugs
AZD5991
4 more in the full profile.
07
Biomarkers
MCL-1 expression levels
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