Induced pluripotent stem cell reprogramming via Yamanaka factors (iPSC reprogramming (Yamanaka factors))

Cellular differentiation potential restoration via Yamanaka factor-mediated nuclear reprogramming" refers not to a single molecule or receptor but rather a process in which differentiated somatic cells are reverted back into an embryonic-like pluripotent state. This is achieved by introducing four key transcription factors—OCT4, SOX2, KLF4, and c-MYC—collectively known as the "Yamanaka factors." These proteins act on the genome to erase cell-type-specific epigenetic marks and reactivate genes associated with stemness. The resulting induced pluripotent stem cells (iPSCs) can then be directed toward various cell fates for research or therapeutic purposes. While this technology has revolutionized regenerative medicine research by providing an alternative source for patient-specific stem cells without using embryos[1], it is not itself a druggable target but rather describes a method/process involving multiple molecular targets. The process shares molecular pathways with cancer biology due to its reliance on proliferation and dedifferentiation mechanisms.[1][2]

Other names

Yamanaka factor-mediated nuclear reprogrammingOSKM-mediated cellular reprogrammingInduced pluripotency via Yamanaka factorsCellular dedifferentiation by OSKM

Induction of epigenetic changes and activation of signaling pathways that revert differentiated cells to a pluripotent state; inhibition of HDACs and TGFβ signaling; activation/inhibition of Wnt/β-catenin and MAPK pathways[1][2]