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Target intelligence / Profile preview
Inducible Caspase-9 (iCasp9)
- Target
- iCasp9
- Molecular classification
- Enzyme, Caspase, Apoptosis regulator, Fusion protein
01
Overview
Inducible caspase-9 (iCasp9) is a synthetic, engineered form of the human caspase-9 protein designed to function as a "suicide gene" in genetically modified cells. It is activated by small-molecule dimerizers (AP1903/Rimiducid or AP20187), resulting in rapid apoptosis. It is primarily used as a safety switch in adoptive immunotherapies such as CAR-T cell therapy to eliminate transduced cells in case of severe adverse events.
- Other names
- iCasp9Inducible caspase 9Suicide gene
02
Mechanism of action
Small-molecule-induced dimerization, leading to caspase-9 activation and apoptosis
03
Biological functions
ApoptosisCell deathSafety switch
04
Disease associations
CancerGraft-versus-host diseaseAutoimmune disorders
05
Safety considerations
Potential for incomplete cell eliminationOff-target effects of dimerizer drugsImmunogenicity of engineered protein
06
Interacting drugs
AP1903
2 more in the full profile.
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