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Target intelligence / Profile preview
Inducible Caspase 9 Suicide Switch (iCasp9)
- Target
- iCasp9
- Molecular classification
- Fusion Protein, Enzyme, Apoptosis regulator
01
Overview
The inducible caspase 9 (iCasp9) suicide switch is a genetically engineered safety mechanism designed to selectively induce apoptosis in modified cells, such as T cells used in adoptive cell therapies. This system provides a rapid and controllable way to eliminate therapeutic cells if severe adverse effects or off-target toxicities occur, thereby improving the safety profile of cellular immunotherapies. It consists of the intracellular domain of human caspase-9 fused to a modified drug-binding domain from human FKBP12. Activation requires a small-molecule CID like AP1903/Rimiducid, which dimerizes iCasp9, triggering apoptosis.
- Other names
- iCasp9 Suicide SwitchInducible Caspase-9iCasp-9Chemically Inducible Caspase 9
02
Mechanism of action
Dimerization and activation of caspase-9, leading to downstream activation of effector caspases and apoptosis
03
Biological functions
Apoptosis inductionCell deathSafety switch for cell therapies
04
Disease associations
CancerAutoimmune Diseases
05
Safety considerations
Drug-resistant subclonesOff-target effects of therapeutic cellsCytokine Release SyndromeGraft-versus-host disease
06
Interacting drugs
AP1903
1 more in the full profile.
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