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Target intelligence / Profile preview
Inducible T-cell Co-stimulator Protein (ICOS)
- Target
- ICOS
- Molecular classification
- Type I transmembrane glycoprotein, CD28/CTLA-4 superfamily, Receptor
01
Overview
Inducible T-cell Co-stimulator (ICOS), also known as CD278, is a co-stimulatory receptor expressed primarily on activated T cells. It belongs to the CD28/CTLA-4 superfamily and plays a crucial role in T-cell activation, proliferation, cytokine production, and survival. ICOS interacts with its ligand, ICOS-L (B7RP-1), which is expressed on antigen-presenting cells and B cells. This interaction is essential for T-dependent humoral immunity, Tfh cell differentiation, and the regulation of immune responses. ICOS is implicated in various diseases, including Common Variable Immunodeficiency type 1 (CVID1), autoimmunity, and cancer, making it a potential therapeutic target.
- Other names
- CD278AILIMCVID1inducible T-cell costimulator
02
Mechanism of action
Agonist antibodies to boost anti-tumor immunity
03
Biological functions
T-cell co-stimulationT-cell activationT-cell proliferationCytokine secretionT-cell survivalTfh cell differentiationAntibody responseImmune regulation
04
Disease associations
Common Variable Immunodeficiency type 1 (CVID1)AutoimmunityCancer
05
Safety considerations
Complex and context-dependent roles in autoimmunityPotential for immune-related adverse events with agonist antibodies
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