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Target intelligence / Profile preview
Inducible T-cell costimulatory receptor CD137 (4-1BB)
- Target
- 4-1BB
- Molecular classification
- Receptor, Tumor necrosis factor receptor superfamily
01
Overview
CD137/4‑1BB is an inducible costimulatory receptor critical for robust adaptive immune responses through enhancement of cytotoxic lymphocyte function. Its manipulation—either stimulation via agonists or inhibition via antagonists—is central to emerging therapies across oncology, autoimmunity, infectious diseases, and cardiovascular inflammation.
- Other names
- TNFRSF9CDw137ILA
02
Mechanism of action
Agonist activation of CD137 enhances T cell activation, proliferation, survival, and cytokine production. Antagonists of CD137 reduce T cell activation and cytokine production.
03
Biological functions
Immune responseT cell activationCell proliferationCell survivalSignal transductionCytokine production
04
Disease associations
CancerAutoimmunityInflammationCardiovascular diseaseInfection
05
Safety considerations
Potential for exacerbating autoimmune conditionsPotential for impairing antiviral immunityToxicity related to immune overactivation
06
Interacting drugs
Agonist monoclonal antibodies targeting CD137
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