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Induction of Anti-Tumor Immune Response
- Molecular classification
- Immune Response, Biological Process
01
Overview
The induction of an anti-tumor immune response refers to the activation and mobilization of the host's immune system to recognize, target, and eliminate cancer cells. This process involves both innate and adaptive immunity, with a central role played by cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, dendritic cells (DCs), and various cytokines. The goal is to overcome tumor-induced immunosuppression and generate a robust, sustained immune attack against malignant cells.
02
Mechanism of action
Various, including: - Blockade of immune checkpoints (PD-1/PD-L1, CTLA-4) to enhance T cell activity - Stimulation of immune cells via cytokine signaling (e.g., IL-18 promoting IFN-γ production) - Induction of immunogenic cell death (ICD) by radiotherapy or chemotherapy, leading to DAMP release and DC activation - Activation of innate immune pathways (e.g., cGAS/STING) by tumor-derived DNA
03
Biological functions
Immune responseCell deathAntigen presentationCytokine signaling
04
Disease associations
Cancer
05
Safety considerations
Immune-related adverse events (irAEs) associated with checkpoint inhibitors (e.g., colitis, pneumonitis, endocrinopathies)Cytokine release syndrome (CRS) with cytokine therapiesOff-target effects of immunotherapiesDevelopment of resistance to immunotherapy
06
Interacting drugs
Checkpoint inhibitors (e.g., anti-PD-1, anti-PD-L1, anti-CTLA-4)
3 more in the full profile.
07
Biomarkers
PD-L1 expression in tumor cellsTumor mutational burden (TMB)Microsatellite instability (MSI)Presence of tumor-infiltrating lymphocytes (TILs)Expression of specific tumor-associated antigens
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