Induction of Anti-Tumor Immune Response Through Immunogenic Cell Death and Immune Infiltration (ICD-mediated Anti-Tumor Immunity)

The induction of anti-tumor immune responses through immunogenic cell death (ICD) and subsequent immune infiltration is a therapeutic strategy that leverages the body’s own immune system to recognize, attack, and remember tumor cells. This process involves regulated forms of cell death in cancer cells that actively stimulate both innate and adaptive immunity, leading to durable anti-tumor effects. Key components include the release of DAMPs, activation of dendritic cells, and T cell-mediated cytotoxicity.

Other names

Immunogenic Cell DeathICDDAMP-mediated immune responseAnti-tumor immunityTumor Microenvironment Modulation

Induction of immunogenic cell death (ICD) leading to release of DAMPs, activation of antigen-presenting cells (APCs), and subsequent T cell-mediated anti-tumor immunity.