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Induction of cellular immunity
- Molecular classification
- Other (not a molecule, receptor, or classic target), Could involve: T cell receptor, cytokines, Major histocompatibility complex (MHC), but these are components, not synonyms
01
Overview
Induction of cellular immunity refers to the activation of immune responses mediated primarily by T lymphocytes (especially cytotoxic CD8+ T cells), macrophages, and cytokines, as opposed to antibody-mediated (humoral) immunity. This process is critical for defense against intracellular pathogens (such as viruses and certain bacteria), tumor cells, and allografts. Cellular immunity involves antigen presentation via MHC molecules, subsequent T cell activation and clonal expansion, recognition of infected or abnormal cells, and their direct destruction or modulation by immune effectors. "Induction of cellular immunity" is not a molecule or receptor, but rather a key function of the adaptive immune system.
- Other names
- Cellular immunityCell-mediated immunity
02
Mechanism of action
Not applicable to the process itself; relevant mechanisms include activation or inhibition of T cells, modulation of MHC expression, cytokine production, and inhibition of co-stimulatory molecules
03
Biological functions
Immune responseDestruction of virus-infected or cancerous cellsRecognition of intracellular pathogensCytotoxicityCytokine secretion
04
Disease associations
CancerInfection (especially viral and certain intracellular bacterial infections)Inflammation
05
Safety considerations
Risk of autoimmune reactionsCytokine release syndromeGraft-versus-host disease (GVHD) in transplantation
06
Interacting drugs
Immune checkpoint inhibitors (e.g., pembrolizumab, nivolumab, ipilimumab)
2 more in the full profile.
07
Biomarkers
Levels of cytotoxic T lymphocytes (CD8+ T cells)Interferon-gamma release assaysExpression of activation markers on T cells (e.g., CD69, CD25)MHC expression on antigen-presenting cells
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