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Induction of Immune Tolerance via Repeated Exposure to Dermatophagoides pteronyssinus Allergens
- Molecular classification
- Immune process, Tolerance induction
01
Overview
The process of inducing immune tolerance to allergens from *Dermatophagoides pteronyssinus* (house dust mite) through repeated exposure. This involves complex cellular and molecular mechanisms that shift the immune response from an allergic (Th2-dominated) profile toward a tolerant state characterized by regulatory T cell induction, anti-inflammatory cytokine production, and antibody class switching.
- Other names
- D. pteronyssinus allergen toleranceHouse dust mite allergen immunotherapyAllergen-specific immunotherapyASIT
02
Mechanism of action
Induction and expansion of allergen-specific regulatory T cells (Tregs), increased production of immunosuppressive cytokines (IL-10, TGF-β), antibody class switching to IgG4, and modulation of dendritic cell function to promote tolerance.
03
Biological functions
Immune toleranceRegulation of immune responseT cell regulationB cell regulationCytokine signaling
04
Disease associations
Allergic rhinitisAsthmaAtopic dermatitisHouse dust mite allergy
05
Safety considerations
AnaphylaxisLocal reactions (e.g., injection site swelling)Exacerbation of allergic symptoms
06
Interacting drugs
Dermatophagoides pteronyssinus extract (allergen immunotherapy)
1 more in the full profile.
07
Biomarkers
Allergen-specific IgE levelsAllergen-specific IgG4 levelsFrequency of allergen-specific TregsIL-10 productionTGF-β production
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