Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Induction of Interferon-Stimulated Genes
- Molecular classification
- Gene expression program, Signaling pathway
01
Overview
The induction of interferon-stimulated genes (ISGs) is a cellular process triggered by interferons (IFNs) that results in the expression of a large set of genes involved in innate immunity, particularly antiviral defense. This process involves IFN binding to its receptor, activation of the JAK-STAT pathway, and translocation of STAT complexes to the nucleus to initiate ISG transcription. ISGs encode proteins that directly inhibit viral replication, modulate immune signaling, and regulate cell fate.
- Other names
- ISG InductionInterferon ResponseType I Interferon ResponseType II Interferon ResponseType III Interferon Response
02
Mechanism of action
Interferons bind to cell surface receptors, activating the JAK-STAT signaling pathway, leading to the transcription of interferon-stimulated genes (ISGs).
03
Biological functions
Innate immunityAntiviral defenseImmune response modulationRegulation of transcriptionCell signalingCytokine production
04
Disease associations
InfectionAutoimmune diseaseChronic inflammationCancer
05
Safety considerations
Cytokine stormAutoimmunityImmune suppressionExacerbation of inflammatory conditions
06
Interacting drugs
Interferons (IFN-α, IFN-β, IFN-γ, IFN-λ)
2 more in the full profile.
07
Biomarkers
ISG expression levels (e.g., IFIT1, ISG15, MX1)IFN-α levelsIFN-γ levelsSTAT phosphorylation
Beyond the preview
Go deeper on Induction of Interferon-Stimulated Genes.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Induction of Interferon-Stimulated Genes.