Induction of T cell-mediated immune response via dendritic cell targeting with plasmid DNA encoding multiple HIV antigens

This target refers to a vaccine or immunotherapy strategy that aims to enhance the body's T cell-mediated immunity against HIV by directing antigens specifically to dendritic cells (DCs) using plasmid DNA constructs encoding several HIV-derived epitopes. The approach leverages advances in antigen design, vector engineering, adjuvant science, and our understanding of dendritic cell biology to overcome challenges posed by chronic viral infections such as immune exhaustion/tolerance seen during persistent HIV exposure.

Other names

Dendritic cell-targeted HIV vaccineHIV DNA vaccineT cell-based HIV immunotherapyDC-targeting HIV immunogen

Plasmid DNA encoding multiple HIV antigens is delivered to dendritic cells, leading to antigen processing and presentation, resulting in the activation of CD4+ and CD8+ T cells.