Induction of tumor cell lysis and immunogenic cell death via viral replication

The induction of tumor cell lysis and immunogenic cell death via viral replication refers to a therapeutic strategy using oncolytic viruses. These viruses preferentially infect and replicate within cancer cells, causing cell lysis. The process leads to the release of tumor antigens, DAMPs, and PAMPs, which stimulate both innate and adaptive antitumor immune responses. This mechanism combines direct cytotoxicity with immunological tumor clearance and forms the basis for oncolytic virotherapy—a new class of immunotherapy drugs under investigation for cancer treatment.

Direct lysis of tumor cells by viral replication Release of viral progeny, pathogen-associated molecular patterns (PAMPs), and danger-associated molecular patterns (DAMPs) Induction of immunogenic cell death and subsequent antitumor immunity