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Target intelligence / Profile preview
Infected Cell Protein No. 34.5 (ICP34.5)
- Target
- ICP34.5
- Molecular classification
- Viral Protein
01
Overview
ICP34.5 is a multifunctional neurovirulence factor of herpes simplex virus type 1 (HSV-1). It plays essential roles in viral replication, evasion of host immune responses, and pathogenesis within the nervous system. It counteracts host antiviral responses by recruiting protein phosphatase 1 alpha (PP1α) to dephosphorylate eIF2α, reversing host-induced translational shutoff. It also interacts with Beclin 1 to inhibit autophagy. Loss or mutation in ICP34.5 leads to reduced neurovirulence, impaired replication, increased immune recognition, and attenuated pathogenicity.
- Other names
- RL13 product
02
Mechanism of action
Recruits protein phosphatase 1 alpha (PP1α) to dephosphorylate eIF2α, reversing host-induced translational shutoff. Interacts with Beclin 1 to inhibit autophagy.
03
Biological functions
NeurovirulenceCounteraction of host antiviral responseDephosphorylation of eIF2αModulation of autophagyImmune evasionViral replicationNuclear egress of capsids
04
Disease associations
InfectionHerpes simplex virus type 1 infectionNeurological disease
05
Safety considerations
Targeting ICP34.5 could potentially affect normal cellular autophagy processes.Inhibition of ICP34.5 may lead to increased immune recognition and inflammation.
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