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Infected cell via Fc effector function
- Molecular classification
- Immune effector pathway, Fc receptor signaling
01
Overview
The term "Infected cell via Fc effector function" refers to the targeting and elimination of pathogen-infected cells by immune mechanisms that are mediated through the Fc (fragment crystallizable) region of antibodies. This process involves antibody binding to infected cells and the recruitment of immune effector functions through Fc receptor interactions, leading to ADCC, ADCP, or CDC.
- Other names
- Antibody-dependent cellular cytotoxicity (ADCC)Antibody-dependent cellular phagocytosis (ADCP)Complement-dependent cytotoxicity (CDC)Fc effector function
02
Mechanism of action
Antibodies bind to antigens on infected cells, and the Fc region of the antibody interacts with Fc receptors on immune cells, triggering ADCC, ADCP, or CDC.
03
Biological functions
Target cell lysisPhagocytosisImmune responseViral clearanceMicrobial clearance
04
Disease associations
Viral infectionBacterial infectionImmune defenseCancer (potential therapeutic application)
05
Safety considerations
Cytokine release syndromeOff-target effectsAutoimmunity
06
Interacting drugs
Therapeutic monoclonal antibodies
1 more in the full profile.
07
Biomarkers
Antibody titersFc receptor polymorphismsNK cell activityMacrophage activityComplement activation
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