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Infected host cell presenting SARS-CoV-2 antigens via major histocompatibility complex
- Molecular classification
- Cell, Major Histocompatibility Complex
01
Overview
An infected host cell presenting SARS-CoV-2 antigens via the major histocompatibility complex (MHC) refers to a cell that has been invaded by the SARS-CoV-2 virus and is displaying viral peptide fragments on its surface using MHC molecules. This process is central to activating adaptive immune responses, as it allows T cells to recognize and respond to infected cells. SARS-CoV-2 has evolved strategies to interfere with this process, including downregulation of MHC molecules and interference with antigen processing, leading to impaired T cell activation and viral persistence.
- Other names
- SARS-CoV-2 antigen presentationMHC-I/II SARS-CoV-2 peptide complexViral antigen presentation by infected cells
02
Biological functions
Antigen presentationT cell activationImmune response
03
Disease associations
COVID-19 pathogenesisViral persistenceImmune evasion
04
Safety considerations
Immune evasion by SARS-CoV-2Downregulation of MHC moleculesImpaired antigen processing
05
Biomarkers
MHC-I surface expressionMHC-II surface expressionViral peptide presentationT cell activation markers
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