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Inflamed Epithelium

Molecular classification: Tissue state, Cellular phenotype

Overview

Inflamed epithelium refers to epithelial tissue undergoing an inflammatory response. The epithelium, a layer of cells covering body surfaces and lining cavities, acts as a dynamic barrier and plays a critical role in immune regulation. Inflammation disrupts the epithelial barrier, leading to increased permeability and recruitment of immune cells. It is central to many diseases such as asthma, chronic rhinosinusitis, inflammatory bowel disease, and others.

Biological functions

Barrier protectionRegulation of local immunityMediator of inflammation

Disease associations

AsthmaChronic RhinosinusitisInflammatory Bowel DiseaseSkin DisordersInflammation

Biomarkers

Upregulation/secretion of cytokinesUpregulation/secretion of chemokinesUpregulation/secretion of growth factors

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