Inflammation pathway in epidermal cells

The "inflammation pathway in epidermal cells" refers to a collection of interconnected signaling cascades and molecular events triggered by pathogen exposure, tissue damage, or stress in skin (epidermal) cells. Key molecular players include transmembrane toll-like receptors (TLRs), cytosolic NOD-like receptors (NLRs), and key transcription factors such as NF-κB, which together regulate the expression of inflammatory cytokines like IL-1β, TNF-α, and IL-6. Additional pathways involved include the MAP kinase (MAPK) and JAK-STAT pathways, both of which mediate responses downstream of cytokine and growth factor receptors. Epidermal inflammation serves essential roles in host defense, wound repair, and immune system activation; however, its dysregulation can promote chronic skin diseases, autoimmune conditions, or inflammation-associated carcinogenesis. Many drugs and therapeutic agents target specific receptors or signaling proteins within these pathways, rather than the pathway as a unified target.

Other names

Inflammatory signaling in epidermal cellsSkin cell inflammatory pathwayEpidermal cell inflammation cascade