Inflammatory and coagulation pathways

The term "inflammatory and coagulation pathways" refers to the tightly linked biological processes by which inflammation and blood coagulation regulate and influence each other. Central molecules include coagulation factors (such as fibrinogen, thrombin, factor XII), platelets, tissue factor, and a variety of inflammatory cytokines. During acute injury, infection, or chronic disease, activation of coagulation can amplify inflammatory signals, while inflammation itself propagates coagulation activity, notably via tissue factor induction on immune and vascular cells. This interaction is vital for host defense but can lead to pathologies such as thrombosis, disseminated intravascular coagulation, and organ dysfunction in conditions like sepsis and autoimmune diseases. Therapeutic approaches often target individual components of these cascades, including anticoagulant and antiplatelet drugs, but the "inflammatory and coagulation pathways" as a whole do not constitute a single druggable entity[2][4][6].

Other names

Inflammation–coagulation axisthrombo-inflammationthromboinflammatory pathwaysinflammatory-coagulation network

Anticoagulation (inhibition of clotting factor activity); Antiplatelet effects (inhibition of platelet activation/aggregation); Modulation of endothelial or leukocyte activity; Fibrinolysis (breakdown of fibrin clots); Immune modulation