Inflammatory and proliferation signaling pathways

The term "Inflammatory and proliferation signaling pathways" describes a group of cellular communication networks that govern both inflammatory responses and cell proliferation. Prominent among these are the NF-κB, MAPK, and JAK-STAT pathways, all of which play fundamental roles in transmitting signals from cytokines, growth factors, and cellular stress to modulate gene expression critical for immune activation, inflammation, and tissue growth[1][3][4][5]. Pattern recognition receptors such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), and others act upstream to detect pathogenic or endogenous danger signals and initiate these signaling cascades[1][3][4][5]. Dysregulation of these pathways can result in chronic inflammation, autoimmune conditions, uncontrolled cell proliferation, and cancer[2][3]. Specific proteins or kinases within these pathways (such as JAKs, MAPKs, NF-κB subunits, or TLRs) are considered valid drug targets, but the phrase itself is not a druggable target nor a canonical molecule. In summary, "Inflammatory and proliferation signaling pathways" is not a single canonical target but a broad biological concept encompassing numerous drug targets and molecular families involved in inflammation and cell proliferation. For structured drug development or database use, these entries must be mapped to specific pathway nodes or individual molecules.

Other names

Inflammatory and proliferative signaling pathwaysInflammatory signaling pathwaysProliferation signaling pathwaysInflammation pathwaysCell proliferation pathways