Inflammatory cytokine (skin)

Inflammatory cytokines in skin is not a single molecule or receptor but rather a collective term for a group of signaling proteins—primarily interleukins (such as IL‑1β, IL‑6, IL‑17A/F/C/E/IL‑22), tumor necrosis factor alpha (TNFα), interferons and others—that are produced by keratinocytes and immune cells within the skin. These molecules act as key modulators of the immune system and inflammation. They initiate their biological action by binding to specific receptors on target cells—including keratinocytes themselves—triggering cascades that regulate cell proliferation, differentiation and recruitment of additional immune cells[1][2][5]. Dysregulation or overproduction of these cytokines is central to the pathogenesis of many inflammatory skin diseases such as psoriasis and atopic dermatitis[1][2][7]. Targeted therapies exist for some individual members within this group—for example monoclonal antibodies against interleukin 17A—but "inflammatory cytokines in skin" itself does not refer to a single druggable entity or canonical molecular target. Note: This entry is considered incorrect as a therapeutic target because it refers to an entire class/family rather than an individual molecule/receptor. For structured data purposes you should map queries like this to their constituent canonical targets where possible—such as "Interleukin 17A", "Tumor necrosis factor alpha", etc.—rather than use this generic grouping.

Other names

Pro-inflammatory cytokines in skinSkin inflammatory cytokinesCutaneous inflammatory cytokines

Monoclonal antibody antagonism of specific interleukins (e.g., IL‑17A inhibition by secukinumab)[3]