Inflammatory Cytokine Production by Immune Cells (None)

Inflammatory cytokine production by immune cells refers to the synthesis and secretion of specific signaling proteins—cytokines—that promote inflammation. These molecules are primarily produced by immune cells such as macrophages, monocytes, dendritic cells, helper T cells (Th1 and Th17), neutrophils, mast cells, basophils, natural killer (NK) cells, and innate lymphoid cells. The process is a central component of the body’s defense mechanism against pathogens or injury but can also contribute to chronic inflammatory diseases if dysregulated. Key cytokines include IL‑1β/α, IL‑6, TNF‑α, IFNγ, IL‑12, IL‑17 and IL‑18. Therapeutic strategies often target these pathways using monoclonal antibodies against specific pro-inflammatory cytokines or their receptors.

Neutralization of inflammatory cytokines or their receptors