Inflammatory mediator adsorption

Inflammatory mediator adsorption refers to a therapeutic approach utilizing materials or devices capable of binding and removing proinflammatory proteins (such as HMGB1, cytokines, chemokines, and DAMPs) from blood or extracellular fluids. This process is non-selective and typically uses hydrophobic or charged polymers engineered to maximize surface area and adsorptive capacity. The goal is to reduce excessive or harmful inflammatory responses observed in conditions like sepsis or autoimmune disease. "Inflammatory mediator adsorption" is not a molecular target itself, but rather a modality for treating inflammatory diseases by physically removing causative proteins.

Physical adsorption of proinflammatory molecules (e.g., cytokines, DAMPs) onto biocompatible polymers or other materials. Reduction of systemic or local inflammation by removal of effectors from circulation or tissue fluids.