Inflammatory Mediator Expression Inhibitor

An "inflammatory mediator expression inhibitor" is a functional class of agents—small molecules, biologics, or natural compounds—that suppress the production or activity of inflammatory mediators. These mediators include cytokines (e.g. TNF-α, IL-1β), chemokines, prostaglandins, and other signaling molecules that drive inflammation in various diseases. They act by interfering with key signaling pathways and transcription factors responsible for the synthesis and release of pro-inflammatory molecules. Common mechanisms include: Inhibition of Transcription Factors, Kinase Inhibition, Modulation of Signaling Pathways.

Blocks synthesis/release/activity of pro-inflammatory mediators via NF-kB/AP1/MAPK/CDK8-CDK19/NLRP3 inflammasome pathways.