Inflammatory mediator in airway mucosa

Inflammatory mediators in airway mucosa are a collective term for diverse proteins, peptides, and bioactive molecules released by immune and structural cells in the airway, including epithelial cells, mast cells, eosinophils, and fibroblasts. These mediators (cytokines, chemokines, amines, eicosanoids, adhesion molecules) orchestrate the immune and inflammatory response in the respiratory tract, leading to cellular recruitment, vascular changes, and tissue remodeling typical of diseases like asthma, COPD, and allergic airway disorders. Therapeutic targeting typically focuses on specific mediators (e.g. IL-5, IL-4, TNF-α), not the broad functional category encompassed by the term "inflammatory mediators".

Other names

Inflammatory mediators of airway mucosaAirway inflammatory mediatorsAirway mucosal inflammatory moleculesImmune mediators in respiratory tract

Inhibition of cytokine synthesis and activity (blocking IL-4, IL-5, IL-13, IL-33); Antagonism of leukotriene and histamine receptors; Reduction of immune cell infiltration (interfering with adhesion molecules); Suppression of signal transduction pathways (e.g. NF-κB, MAPK).